Great Toenail Dystrophy: A Single-Center Experience and Review of the Literature / 가정의학회지

BACKGROUND: There have been a few reported cases of congenital great toenail dystrophy (GTND), described as a congenital malalignment of the great toenails. However, acquired GTDN is rare, and has not been documented extensively. This study aimed to describe the clinical features of 21 patients with acquired GTND. METHODS: Twenty-one patients with acquired GTND who visited Yeouido St. Mary's Hospital between June 2005 and August 2012 were retrospectively reviewed. RESULTS: The mean patient age was 43.1 years (range, 17 to 88 years), and the cohort predominantly comprised women (18/21). In our experience, all acquired GTND patients presented with yellow or yellow-brownish chromonychia, onychotrophy, and onycholysis. Conservative treatment with tape methods and grinding, as well as nail extraction, was provided and yielded little improvement in any case. CONCLUSION: This study provides initial data on the nail changes affecting the great toenail, such as yellowish chromonychia, onychomadesis, and onycholysis. These data may help physicians to distinguish various nail disorders, including onychomycosis, congenital malalignment of the great toenails, and yellow nail syndrome.

Unusual manifestation of the yellow nail syndrome - Case report

The yellow nail syndrome is a rare disorder characterized by the classic triad of yellow and dystrophic nails, lymphedema and pleural effusion. We report in this paper a case of yellow nail syndrome, presenting the classic triad of the disease, associated with an unusual lymph accumulation in the abdomen region.

Mujer anciana con el síndrome de las uñas amarillas, artritis reumatoide e hipotiroidismo / Elderly woman with yellow nail syndrome, rheumatoid arthritis and hypothyroidism

The yellow nail syndrome is a scarcely reported condition, and its physiopathology is not well understood. The main characteristics of this syndrome are yellowish discoloration of the nail plates, pulmonary changes and pleural effusion, and lymphedema of the lower limbs. Case Report An 85-year-old Brazilian woman, with history of bronchial asthma, rheumatoid arthritis and arterial hypertension, was complaining of breathlessness, lower limb edema, and intense oliguria. Over the previous 40 years she had been treated with aurothioglucose, prednisone, and NSAIDs. Yellowish nail changes developed in her hand and toe fngers, and lung and pleural changes were detected by chest radiography and computerized tomography. With evidence of classical triad, the yellow nail syndrome was characterized. Laboratory tests showed elevated levels of TSH and normal levels of free-T4, establishing the additional diagnosis of subclinical hypothyroidism. Conclusion The purpose of this report is to discuss uncommon associated conditions with yellow nails syndrome, which is considered a rare clinical entity.

El síndrome de las uñas amarillas es una condición escasamente reportada, y su fsiopatología no es bien entendida. Las principales características de este síndrome son la decoloración amarillenta de las placas de las uñas, alteraciones pulmonares y efusión pleural, y linfedema de las extremidades inferiores. Presentación de caso Mujer brasileña, 85 años de edad, con antecedentes de asma bronquial, artritis reumatoide y hipertensión arterial se quejaba de falta de aire, edema de miembros inferiores y oliguria intensa. Durante los últimos 40 años había sido tratada con aurotioglucosa, prednisona, y AINEs. Uñas amarillas desarrollaron en los dedos de manos y pies, y cambios pulmonares y pleurales fueron detectados por radiografía de tórax y tomografía computarizada. Con evidencia de la tríada clásica, se caracterizó el síndrome de las uñas amarillas. Las pruebas de laboratorio mostraron niveles elevados de TSH, con niveles normales de T4 libre, y se estableció el diagnóstico adicional de hipotiroidismo subclínico. Conclusión El propósito de este informe es analizar condiciones poco comunes asociadas con el síndrome de las uñas amarillas, que se considera una entidad clínica rara. CASE REPORT Recibido: 06 ­ November ­ 2014 Aceptado: 01 ­ December ­ 2014 Key words: Rheumatoid arthritis; Subclinical hypothyroidism; Yellow nail syndrome; Case report. Revista Médica Vozandes Volumen 25, Número 1-2, 2014 This article is licensed under a Creative Commons Attribution ­ Non Commercial ­ No Derivatives 4.0 International Licence Resumen Mujer anciana con el síndrome de las uñas amarillas, artritis reumatoide e hipotiroidismo Palabras clave: Artritis reumatoide; Hipotiroidismo subclínico; Síndrome de las uñas amarillas; Rep

Nails: Diagnostic clue to genodermatoses.

Nails are cutaneous appendages mostly involved in mechanical functions. However, nails may reflect presence of various systemic disorders evidenced by alteration of their shape, size, color or texture. Genodermatoses are multisystem disorders with cutaneous involvement. Many of the genodermatoses present with nail changes and some of these may be the clinical pointers to the diagnosis. Diagnostic clues to various genodermatoses derived from nail findings have been discussed.

A Case of Yellow Nail Syndrome: Misdiagnosis as Congestive Heart Failure / 결핵및호흡기질환

Yellow nail syndrome (YNS) is a rare disorder of unknown cause associated with yellow nails, lymphedema and respiratory manifestations. It was first described by Samman and White in 1964, and to date, approximately 150 cases have been reported. The diagnosis of YNS is essentially a clinical one and based on the presence of characteristic findings. We report a case of YNS of a 62-year-old female who presented with a 4-month history of dyspnea and recurrent pleural effusion. The patient had a 5-year history of leg swelling and dyspnea. She had been managed with medications for congestive heart failure (CHF) for two years and she was referred to our hospital for further evaluation and management.

Unhas meio a meio e síndrome das unhas amarelas em pacientes hemiplégicos com insuficiência renal / Half-and-half nails and yellow nail syndrome in hemiplegic patient with renal failure

Insuficiência renal crônica tem sido associada com várias alterações ungueais, devidas à condição renal ou ao tratamento. Unhas meio-a-meio constituem o achado mais comum. A síndrome das unhas amarelas se caracteriza por unhas amarelas, edema linfático e distúrbios respiratórios. Além disso, alterações ungueais podem desenvolver com o envelhecimento, incluindo-se modificações na velocidade de crescimento, cor, contorno, superfície, e espessura. Unhas meio-a-meio e unhas amarelas são descritas em um homem de 85 anos, com seqüela de hemiplegia direita e insuficiência renal. As unhas meio-a-meio foram observadas exclusivamente na mão paralisada. É possível que fatores patogênicos da síndrome tiveram influência de distúrbios vasculares locais no leito ungueal, secundários à hemiplegia. Assim, os dedos da mão direita poderiam ser poupados das alterações de unhas amarelas, desenvolvendo características de unhas meio-a-meio. Embora ambas condições ocorram em idosos e em renais crônicos, a coexistência de síndrome das unhas amarelas e unhas meio-a-meio é muitíssimo rara.

Chronic renal failure has been associated with several nail changes due to renal condition or to the treatment. Half-and-half nails constitute the most common finding. The yellow nail syndrome is characterized by yellow nails, lymph edema and respiratory disturbances. Moreover, nail disorders may develop with ageing, including changes in the growth rate, color, contour, surface, and thickness. Half-and-half nails and yellow nails are described in 85-year-old male with brachial sequel of right hemiplegia and renal failure. The half-and-half nails were exclusively observed in the paralyzed hand. It is possible that pathogenic factors of the syndrome were under the influence of local disturbances in nail-bed vessels secondary to hemiplegia. Thus, the right fingers could be spared of yellow nail changes and developed the half-and-half nail features. Although both conditions may occur in elderly and chronic renal patients as well, yellow nail syndrome coexistent with half-and-half nails is exceedingly rare.

Yellow nail syndrome and adnexal tumour: Causal or casual association.

The yellow nail syndrome is an uncommon condition characterised by dystrophic nails, pulmonary disturbances and lymph oedema. In Brazil as well as in India, this syndrome has been scarcely described, at least in part due to diagnosis pitfalls related with darker skin pigmentation. A case of adnexal malignancy developing several decades after initial signs of yellow nail syndrome is reported in a 61-year-old Brazilian female admitted for evaluation of peripheral oedema. She reported recurrent sinusitis and bronchitis, and three antecedent pneumonias. Physical examination showed yellow thickened nails and lower limb oedema, and a painless huge adnexal mass. Diverse tumours have been described associated with yellow nail syndrome; however, associations can also occur by chance. The present report attempts to raise the awareness about casual co-existence of malignancy and the syndrome.

A Case of Yellow Nail Syndrome Manifesting as Chronic Recurrent Pleural Effusion / 결핵및호흡기질환

Yellow nail syndrome is a rare cause of pleural effusions. This syndrome is characterized by yellow discoloration of nails, lymphedema, and respiratory disorders, including pleural effusion, chronic bronchitis, bronchiectasis, and chronic sinusitis. The etiology of this syndrome is obscure, but the pathogenesis seems to be related with impaired lymphatic drainage. We report a case of yellow nail syndrome in a 70-year-old female with the typical clinical findings (yellow discoloration of nails, lymphedema, and chronic pleural effusion) of this disorder and with proven lymphatic obstruction on lymphoscintigraphy.

A Case of Yellow Nail Syndrome / 대한피부과학회지

We report a 58 year old man who complained that his nails didn't grow for a year and developed yellowish discoloration. On physical examination his nails showed yellow greenish discoloration, increased corvexity, loss of lunulae and cuticles. C]iest X ray revealed atelectasis on right lower lung field and bronchiectasis on left lower lung field. Mild restrictive pattern was observed in pulmoniry function test. We gave him 800IU of Vitamin E claily for 3 months, but rio remarkable changes have been observed as yet..